文献类型：会议

作　　者：朱慧文 李彦庆 周一鸣 宋海坤 刘星 马兰

作者单位：复旦大学基础医学院药理研究中心

会议文献：中国生理学会第24届全国会员代表大会暨生理学学术大会论文汇编

会议名称：中国生理学会第24届全国会员代表大会暨生理学学术大会

会议日期：20141024

会议地点：中国上海

主办单位：中国生理学会

出版日期：20141024

学会名称：中国生理学会

语　　种：中文

摘　　要：Drug relapse is a major clinical problem mainly caused by maladaptive drug memory.Disruption of drug memory would reduce relapse susceptibility.In this study,we used drug retrieval procedure to investigate the role ofβ-adrenergic receptor(β-AR)in addiction memory reconsolidation.Rats were injected propranolol(β-AR antagonist),betaxolol(β1-AR antagonist),ICI-118,551 HCl(β2-AR antagonist)immediately after drug memory retrieval with self-administration of cocaine(3mg/kg).Our data showed thatβ-AR antagonist especiallyβ1-AR antagonist disrupted cocaine seeking behavior 24 h after retrieval and cocaine priming induced memory reinstatement after extinction procedure.On the other hand,β2-AR antagonist had no effect on drug seeking 24 h after retrieval.The data above suggest a potential role ofβ1-AR in addiction memory reconsolidation following cocaine self-administration induced memory retrieval.Blockade ofβ1-AR after drug memory retrieval may be a promising treatment for cocaine relapse.

关 键 词：drug memory  RECONSOLIDATION RELAPSE β-adrenergic receptor  

分 类 号：R338.64[基础医学类]