文献类型：期刊文章

作　　者：赵丹洋[1] 吴伟康[1]

机构地区：[1]中山大学中山医学院病理生理学教研室,广东广州510080

出　　处：《中国病理生理杂志》

年　　份：2004

卷　　号：20

期　　号：4

起止页码：679-682

语　　种：中文

收录情况：BDHX、BDHX2000、CAS、CSCD、CSCD2011_2012、JST、RCCSE、ZGKJHX、核心刊

摘　　要：Oxidative stress has been implicated in brain injury after ischemia, which is a complex cascade. These oxidants produced by oxidative stress are directly involved in oxidative damage with cellular macromolecules such as lipids, proteins and nucleic acids, which lead to cell death. Oxidants are also mediators in signaling involving mitochondria pathway, DNA repair enzymes, and transcription factor that may lead to apoptosis after cerebral ischemia. Antioxidangt enzymes (such as superoxide dismutase,etc) provide useful tools in dissecting the events involving oxidative stress in signaling and damage in ischemic brain injury. This review focuses on the mechanisms of oxidative stress during brain ischemia.

关 键 词：脑缺血 应激 自由基 细胞凋亡

分 类 号：R363]