期刊文章详细信息
胃复春治疗胃粘膜异型增生临床观察及对p21^(ras)和p53表达的调节作用
udy on Weifuchun Pill in the Treatment of Gastric Mucosal Dysplasia and its Regulative Effect on the Expression of P21^(ras) and P^(53) Protein</p> <span class="by"></span>
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<p class='class'><strong>文献类型：</strong>期刊文章</p><p class='author'><strong>作 者：</strong><b class='type_ico_id'></b>张运贵[1] <b class='type_ico_id'></b>孙兆田[2] <b class='type_ico_id'></b>姚桂芹[1] <b class='type_ico_id'></b>韩莉[1] <b class='type_ico_id'></b>薛强[2] </p><p class='en'> </p><p class='organ'><strong>机构地区：</strong><b class='type_ico_id'></b>[1]泰山医学院第二附属医院消化科,济南250031 <b class='type_ico_id'></b>[2]泰山医学院第二附属医院病理科 </p><p class='from'><strong>出 处：</strong><a target='_blank'><b class='type_ico_id'></b></a>《中国中西医结合消化杂志》</p><p class='class'><strong>年 份：</strong>2004</p><p class='class'><strong>卷 号：</strong>12</p><p class='class'><strong>期 号：</strong>2</p><p class='class'><strong>起止页码：</strong>95-97</p><p class='class'><strong>语 种：</strong>中文</p><p class='class'><strong>收录情况：</strong>CAS、IC、RCCSE、ZGKJHX、普通刊</p><p class='abstrack'><strong>摘 要：</strong>目的:研究胃复春片对胃粘膜中、重度异型增生的治疗作用及对p21ras、p53蛋白表达的调节作用,探讨其逆转胃癌前病变的价值及机制。方法:内镜下病理活检证实为中、重度异型增生病例共58例。随机分为胃复春治疗组32例,维酶素对照组26例,治疗前后比较临床疗效,镜下改变、病理改变及粘膜p21ras、p53蛋白S-P法免疫组化染色变化情况。结果:胃复春组临床症状的总有效率81.25％,内镜下改变总有效率71.88％、病理学改变总有效率65.63％,均优于维酶素对照组(分别为53.85％、46.15％、34.61％)。p21ras、p53蛋白在中、重度异型增生组织中有过度表达,胃复春能使其表达明显减弱。结论:胃复春对胃粘膜中、重度异型增生有良好的治疗作用,能促进病变胃粘膜的逆转,并对p21ras、p53蛋白的表达有一定的调节作用,降低癌变危险性,是治疗胃癌前病变的有效药物。</p><p class='subject'><strong>关 键 词：</strong><b class='type_ico_id'></b>胃复春 <b class='type_ico_id'></b>胃粘膜异型增生 临床观察 p21^ras基因 p53基因 蛋白表达 <b class='type_ico_id'></b>免疫组化S-P法 癌前病变 </p><p class='class'><strong>分 类 号：</strong>R259.73[中西医结合类] R285.6] </p>
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