文献类型：期刊文章

作　　者：郭慧淑[1] 崔勋[1] 崔永根[2] 金成柱[3] 曹景宇[3] 李在琉[1] 许文燮[2]

机构地区：[1]延边大学医学院消化生理学研究室 [2]延边大学医学院附属医院中心实验室 [3]全北大学医学院

出　　处：《Acta Pharmacologica Sinica》

基　　金：Project supported by the National Natural Science Foundation of China, № 30160028.

年　　份：2003

卷　　号：24

期　　号：10

起止页码：1021-1026

语　　种：中文

收录情况：AJ、BDHX、BDHX2000、BIOSISPREVIEWS、CAB、CAS、CSA、CSA-PROQEUST、CSCD、CSCD2011_2012、EBSCO、EMBASE、FSTA、IC、JST、PROQUEST、PUBMED、SCI-EXPANDED(收录号：WOS:000185749400012)、SCIE、SCOPUS、WOS、ZGKJHX、核心刊

摘　　要：AIM: To investigate the effect of natriuretic peptides on gastric motility and its possible mechanism. METHODS: Spontaneous contraction of gastric antral circular muscle of rats was recorded by four channel physiograph. The concentration of cyclic guanosine monophosphate(cGMP) was measured by radioimmunoassay. The distribution of natriuretic peptide receptors(NPR) was analyzed by autoradiograph. RESULTS: NPR existed in different regions of rat stomach and its density was the largest in gastric antrum. Atrial natriuretic peptide(ANP), brain natriuretic peptide(BNP), and C-type natriuretic peptide(CNP) all inhibited the spontaneous contraction of gastric antral circular smooth muscle. Among them, the inhibitory effect of CNP on the spontaneous contraction was the most potent and exhibited a dose-dependent manner. CNP-induced inhibition was diminished by LY83583(a kind of inhibitor of guanylate cyclase) and potentiated by zaprinist(a kind of inhibitor of cGMP sensitive phosphoesterase). CNP markedly enhanced the concentration of cGMP in antral smooth muscle. The inhibitory effect of CNP on spontaneous contraction was also inhibited by tetraethylammonium(a nonselective potassium channel blocker, TEA). CONCLUSION: The distribution density of NPR is the most in gastric antrum. CNP significantly inhibits gastric motility in rat gastric antrum. The inhibitory effect occurs via a cGMP dependent pathway and potassium channel is also involved in the relaxation induced by CNP in gastric antrial circular smooth muscle of rat.

关 键 词：C-type natriuretic peptide  pyloric antrum  gastrointestinal motility  cyclic GMP  

分 类 号：R33]