文献类型：期刊文章

作　　者：沈平[1] 王三龙[2] 杨崇仁[3] 蔡兵[2] 姚新生[1]

机构地区：[1]沈阳药科大学,沈阳110016 [2]北京生物医药研究所,北京100091 [3]中国科学院昆明植物研究所,昆明650204

出　　处：《Acta Botanica Sinica》

基　　金：国家重点基础研究发展规划项目 (G19980 5 1113 ) ;植物化学与西部植物资源可持续利用国家重点实验室资助项目~~

年　　份：2003

卷　　号：45

期　　号：5

起止页码：626-629

语　　种：中文

收录情况：CSCD、CSCD2011_2012、SCI-EXPANDED(收录号：WOS:000183077400019)、SCOPUS、WOS、普通刊

摘　　要：Two novel polyhydroxylated steroidal sapogenins, wattigenin B ((25R)-spirost-1beta, 2beta, 3beta, 4beta, 5beta, 6beta, 7alpha-heptol, 1) and wattigenin C ((25S)-spirost-1beta, 2beta, 3beta, 4beta, 5beta, 7alpha-hexalrydroxyl-6-one, 2), together with two known sapogenins, kitigenin (3) and convallagenin B (4), were isolated froth the fresh rhizomes of Tupistra wattii Hook. f. The structures of the compounds were determined on the basis of spectroscopic analysis. The four sapogenins were evaluated for the cytotoxicities on the cancer cell line K562 and A2780a in vitro. Compounds 1 - 4 were obtained from the plant for the first time.

关 键 词：Tupistra wattii  spirostanol sapogenin  CYTOTOXICITY

分 类 号：R284[中药学类]