文献类型：期刊文章

作　　者：蒋惠娣[1] 方伟杰[1] 傅旭春[2] 刘凤兰[1] 胡永州[1]

机构地区：[1]浙江大学药学院,杭州310031 [2]浙江大学城市学院药学系,杭州310015

出　　处：《高等学校化学学报》

基　　金：浙江省中医药局重点项目 (批准号 :G2 0 0 10 3 5 8)资助

年　　份：2003

卷　　号：24

期　　号：12

起止页码：2221-2223

语　　种：中文

收录情况：AJ、BDHX、BDHX2000、CAS、CSCD、CSCD2011_2012、EI、IC、JST、RCCSE、RSC、SCIE、SCOPUS、WOS、ZGKJHX、核心刊

摘　　要：IC 50 values of 13 flavonoids to lipid peroxidation induced by OH · in liver microsomer from rat were evaluated and the relationship between structure and activity was studied. The flavonoids with catechol group, which usually have a higher energy in the highest occupied molecular orbital and lower ΔHOF values, have higher inhibitory activities than those without catechol group. The flavonoids without catechol group in B ring not being suitable structure to chelate with Fe 2+ have little inhibitory activities. The results suggest the anti-lipid peroxidation activity of flavonoids is related with the structure of flavonoids.

关 键 词：黄酮类化合物 药理作用  肝微粒体 脂质过氧化 结构  活性 构效关系 抗氧化活性

分 类 号：R962]