文献类型：期刊文章

作　　者：杜军保[1] 陈晓波[1] 耿彬[2] 蒋宏峰[2] 唐朝枢[2]

机构地区：[1]北京大学第一医院儿科,北京100034 [2]北京大学心血管研究所,北京100034

出　　处：《北京大学学报（医学版）》

年　　份：2002

卷　　号：34

期　　号：2

起止页码：187-187

语　　种：中文

收录情况：BDHX、BDHX2000、CAS、CSCD、CSCD2011_2012、IC、JST、PUBMED、SCOPUS、ZGKJHX、核心刊

摘　　要：To explore the possibility of hydrogen sulfide (H 2S) as a messenger molecule in cardiovascular system, the authors discovered that H 2S (5×10 -5 -5×10 -4 mol·L -1 )exerted an effect on inhibiting endothelin 1 induced proliferation of cultured vascular smooth muscle cells (VSMCs) of rats in vitro . The 3H TdR incorporation decreased by 16.8%～37.4% in H 2S treated VSMCs as compared with the controls ( P <0.01). The inhibitory effect was found to be associated with reduced activity of MAPK. The authors also observed that endogenous H 2S levels markedly increased in vessels of rats with either endotoxic shock or septic shock [H 2S level (pmol·min -1 ·mg -1 ):tail artery (16.18±2.06) vs (8.12±0.55);mesenteric artery (10.17±1.11) vs (6.19 ±0.55);pulmonary artery(11.38±1.24) vs (5.27±0.51); aorta(6.21±0.48) vs (4.10± 0.28), P < 0.01 ]. The above findings suggested that H 2S might play an important role in the regulation of cardiovascular pathophysiologic events.

关 键 词：硫化氢 心血管信号分子  研究  药理学 内皮血管肽类  拮抗剂

分 类 号：R966]