文献类型：期刊文章

作　　者：陈伟[1] 付小兵[1] 盛志勇[1]

机构地区：[1]解放军第304医院全军创伤修复重点研究室,北京100037

出　　处：《Chinese Medical Journal》

基　　金：supported by a grant from the National Natural Science Foundation of China(No．G1999054204)； the National Prominent Youth Science Foundation of China(No．39525024)．

年　　份：2002

期　　号：3

起止页码：446-450

语　　种：中文

收录情况：BIOSISPREVIEWS、CAB、CAS、CSA-PROQEUST、CSCD、CSCD2011_2012、DOAJ、EBSCO、EMBASE、IC、JST、PROQUEST、PUBMED、SCI(收录号：WOS:000174717800032)、SCI-EXPANDED(收录号：WOS:000174717800032)、SCIE、SCOPUS、WOS、ZGKJHX、普通刊

摘　　要：PURPOSE: To review the recent developments in the structure and function of Smad proteins. DATA SOURCES: Both Chinese- and English-language literatures were searched using MEDLINE/CD-ROM (1997 - 2000) and the Index of Chinese-Language Literature (1997 - 2000). STUDY SELECTION: Data from published articles about TGF-beta signal transduction in recent domestic and foreign literature were selected. DATA EXTRACTION: Data were mainly extracted from 22 articles which are listed in the reference section of this review. RESULTS: Smad proteins mediate signal transduction induced by the TGF-beta superfamily. Based on their structural and functional properties, Smad proteins are divided into three groups. The first group, receptor-regulated Smads (R-Smads), are phosphorylated by activated type I receptors and form heteromeric complexes with the second group of Smads, common mediator Smads (Co-Smads). These Smad complexes translocate into the nucleus to influence gene transcription. Inhibitory Smads (I-Smads) are the third group and these antagonize the activity of R-Smads. In the nucleus, Smads can directly contact Smad-binding elements (SBE) in target gene promoters. Through interaction with different transcription factors, transcriptional co-activators or co-repressors, Smads elicit different effects in various cell types. The aberrance of Smad proteins has been noted in several human disorders such as fibrosis, hypertrophic scarring and cancer. CONCLUSION: The structure of Smads determines their function as transcriptional factors which translocate signals from the cell surface to the nucleus where Smads regulate TGF-beta superfamily-dependent gene expression.

关 键 词：DNA-Binding Proteins  Humans  Research Support, Non-U.S. Gov't  Signal Transduction  Smad Proteins  TRANS-ACTIVATORS Transcription Factors  Transforming Growth Factor beta  

分 类 号：R341[基础医学类]