文献类型：期刊文章

作　　者：郭美姿 李孝生[1] 徐海荣[1] 梅浙川[1] 沈薇[1] 叶秀峰[2]

机构地区：[1]重庆医科大学附属第二医院消化内科 [2]重庆医科大学病理科,重庆中国400010

出　　处：《Acta Pharmacologica Sinica》

年　　份：2002

卷　　号：23

期　　号：8

起止页码：739-744

语　　种：中文

收录情况：AJ、BDHX、BDHX2000、BIOSISPREVIEWS、CAB、CAS、CSA、CSA-PROQEUST、CSCD、CSCD2011_2012、EBSCO、EMBASE、FSTA、IC、JST、PROQUEST、PUBMED、SCI-EXPANDED(收录号：WOS:000177314800011)、SCIE、SCOPUS、WOS、ZGKJHX、核心刊

摘　　要：AIM: To investigate the effect of rhein on liver flbrosis induced by the exposure of carbon tetrachloride (CC14)/ ethanol in rats. METHODS: Male Wistar rats were divided into four study groups (n=10 each group): healthy controls, CCl4/ethanol-injured rats left untreated, and CCl4/ethanol-injured rats treated with rhein of low-dose (25 mg·kg-1) and high-dose (100 mg·kg-1). Rhein was given once a day since rat received CCl4/ethanol injury. After administration of rhein for 6 weeks rats were killed. The following parameters were determined: the activity of alanine aminotransferase (ALT), hyalauronic acid (HA) and procollagen type III (PC-Ⅲ) concentrations in serum, liver malondialdehyde (MDA) level, the degree of liver flbrosis, and the expression of α-smooth muscle actin (a-SMA) and transforming growth factor-pi (TGF-β1) in liver tissue. RESULTS: The treatment of rhein markedly reduced the ALT activity, HA and PC-< Ⅲconcentrations, and liver MDA level in CCl4/ethanol-injured rats (P<0.01). It also improved significantly histological changes of flbrosis and decreased the expression of a-SMA and TGF-β1 in liver of these rats (P<0.05 or P<0.01). CONCLUSION: Rhein has protective effect on liver injury and can inhibit liver flbrosis induced by CCl4/ethanol in rats. The mechanisms possibly contribute to its action of antioxidant and anti-inflammatory activity, also associated with its effect of inhibiting TGF-β1 and suppressing the activation of hepatic stellate cells.

关 键 词：RHEIN FIBROSIS carbon tetrachloride  RATS

分 类 号：R96]