文献类型：期刊文章

作　　者：张纬萍[1] 魏尔清[2] 梅如焕[3] 朱朝阳[3] 赵孟辉[3]

机构地区：[1]Department of Biochemistry and Biophysics,University of Pennsylvania Medical School,Philaelphia,PA,19104,USA [2]Correspondence to Prof WEI Wr-Qing [3]浙江大学医学院神经生物学实验室

出　　处：《Acta Pharmacologica Sinica》

基　　金：Project sopported by he National Natural Science Foundation of China,№ 39770270.

年　　份：2002

卷　　号：23

期　　号：10

起止页码：871-877

语　　种：中文

收录情况：AJ、BDHX、BDHX2000、BIOSISPREVIEWS、CAB、CAS、CSA、CSA-PROQEUST、CSCD、CSCD2011_2012、EBSCO、EMBASE、FSTA、IC、JST、PROQUEST、PUBMED、SCI-EXPANDED(收录号：WOS:000178631100002)、SCIE、SCOPUS、WOS、ZGKJHX、核心刊

摘　　要：AIM: To determine whether ONO-1078 (pranlukast), a potent leukotriene receptor antagonist, has neuroprotective effect on focal cerebral ischemia in the rat. METHODS: Focal cerebral ischemia was induced by 30 min of middle cerebral artery (MCA) occlusion and followed by 24 h reperfusion. ONO-1078 (0.003-1.0 mg·kg-1) or vehicle (saline 1 mL·kg-1) was ip injected 30 min before MCA occlusion and 2 h after reperfusion. The neurological score, infarct volume, neuron density (in cortex, hippocampus, and striatum), brain edema, and albumin exudation around the vessels were determined 24 h after reperfusion. RESULTS: ONO-1078 slightly improved the neurological deficiency, and dramatically decreased infarct volume and neuron loss which showed a bell shaped dose response effect with highest effect at doses of 0.01-0.3 mg·kg-1. Enlargement of the ischemic hemisphere and albumin exudation were inhibited at doses of 0.01-1.0 mg·kg-1. CONCLUSION: ONO-1078 has the protective effect on focal cerebral ischemia in rats, which is partially attributed to the inhibition of brain edema. This may represent a novel approach to the treatment of acute cerebral ischemia with cysteinyl leukotriene receptor antagonists.

关 键 词：cerebral ischemia  cerebral arteries  ONO-1078 leukotriene receptor  blood-brain barrier  brain edema  

分 类 号：R96]