文献类型：期刊文章

作　　者：孙华[1] 张庆柱[2] 王如斌[3] 纪建波[4]

机构地区：[1]山东大学药学院药理学教研室 [2]山东大学药学院有机化学教研室 [3]山东大学药学院药理学教研室 济南 [4]中国 250012

出　　处：《Acta Pharmacologica Sinica》

基　　金：Project suported by he Science and Technology Committee of Shandong Province,№ 4138842.

年　　份：2002

卷　　号：23

期　　号：7

起止页码：53-56

语　　种：中文

收录情况：AJ、BDHX、BDHX2000、BIOSISPREVIEWS、CAB、CAS、CSA、CSA-PROQEUST、CSCD、CSCD2011_2012、EBSCO、EMBASE、FSTA、IC、JST、PROQUEST、PUBMED、SCIE、SCOPUS、WOS、ZGKJHX、核心刊

摘　　要：AIM: To study the electrophysiological effects of diacetyl guan-fu base A (DGFA) on pacemaker cells in sinoatrial (SA) node. METHODS: Intracellular micro-electrode method was used to record parameters of action potential (AP) in SA node of rabbits. RESULTS: DGFA could not only slow down spontaneous firing frequency (SFF), mean rate of repolarization (MRR), and rate of diastolic depolarization (RDD), but also prolong diastolic interval (DI) and duration of action potential (APD) in a concentration-dependent manner in SA node. Furthermore, DGFA markedly decreased the maximum rate of depolarization (MRD) with a slight reduce of the amplitude of action potential (APA) and there was no significant effect on the maximal diastolic potential (MDP). The decrease in SFF caused by DGFA was not affected by atropine (0.05 mg/L). CONCLUSION: The effects might be due to the reduction of calcium influx and potassium efflux, and the muscarinic receptors were not involved.

关 键 词：diacetyl guan-fu base A  sinoatrial node  ELECTROPHYSIOLOGY action potentials  

分 类 号：R9[药学类]