文献类型：期刊文章

作　　者：李欣[1] 庞宁[1] 李骥[1] 齐宪荣[1]

机构地区：[1]北京大学医学部药学院药剂学系分子药剂学与新释药系统北京市重点实验室,北京100191

出　　处：《Journal of Chinese Pharmaceutical Sciences》

基　　金：National Natural Science Foundation of China(Grant No.81473156,81673365,81273454);Doctoral Foundation of the Ministry of Education(Grant No.20130001110055);National Key Basic Research Program(Grant No.2013CB932501)

年　　份：2017

卷　　号：26

期　　号：7

起止页码：521-527

语　　种：中文

收录情况：CAB、CAS、CSCD、CSCD2017_2018、DOAJ、EMBASE、IC、JST、SCOPUS、ZGKJHX、普通刊

摘　　要：Drug delivery by nanocarriers requires characterizations of suitable particle size, high drug loading and safety. In this work, we prepared an amphiphilic dendrimer modified PEG-PLA mixed nanoparticles（NPs） by a double emulsion-solvent evaporation（DESE） method. The particle size and drug encapsulation efficacy（EE） were compared to evaluate and optimize the preparation parameters. The mixed NPs had average size ranging from（102±1） nm to（137±5） nm, and the zeta potential turned to positive with incorporation of the amphiphilic dendrimer. The NPs showed different EE of docetaxel（DTX） and paclitaxel（PTX） with higher affinity to more lipophilic PTX. The blank mixed NPs showed little cytotoxicity, and the DTX-loaded NPs could effectively facilitate the antiproliferation activity on PC-3 cells. The NPs could be used as an effective drug delivery system, and its anti-tumor effect is worthy of further study.

关 键 词：PEG-PLA nanoparticles  DOCETAXEL PACLITAXEL Double emulsion-solvent evaporation method  Amphiphilic dendrimer  

分 类 号：R943]