文献类型：期刊文章

作　　者：任伟[1,2] 张爽[1,2] 钟婷[1,2] 黄丹[1,2] 姚鑫[1,2] 郭阳[1,2] 段晓川[1,2] 殷一凡[2] 张漱石[2] 张烜[1,2]

机构地区：[1]北京大学医学部药学院分子药剂学与新释药系统北京市重点实验室,北京100191 [2]北京大学医学部天然药物及仿生药物国家重点实验室,北京100191

出　　处：《Journal of Chinese Pharmaceutical Sciences》

基　　金：Specialized Research Fund for the Doctoral Program of Higher Education(Grant No.20120001110012)

年　　份：2016

卷　　号：25

期　　号：8

起止页码：570-575

语　　种：中文

收录情况：CAB、CAS、CSCD、CSCD2015_2016、IC、SCOPUS、ZGKJHX、普通刊

摘　　要：Theranostics, combining therapy and diagnosis, is an appealing approach for chemotherapy. In the present study, we selected paclitaxel （PTX） as a therapeutic agent, super-paramagnetic iron oxide nanoparticles （SPIO） as a diagnostic agent and sterically stabilized liposomes as a carrier to prepare theranostic liposomes. The SPIO were prepared and characterized. Moreover, the sterically stabilized liposomes containing PTX and SPIO （PTX/SPIO-SSL） were prepared. The characteristics of PTX/SPIO-SSL were investigated. The results indicated that prepared SPIO exhibited super-paramagnetic and could be used for MRI. The average particle size of PTX/SPIO-SSL was about 170 rim, with a polydispersity index （PDI） less than 0.3. The zeta potential of PTX/SPIO-SSL was negative. The PTX entrapment efficiency of PTX/SPIO-SSL was more than 98%. The TEM results indicated the spherical structure and dense SPIO content in PTX/SPIO-SSL. The in vitro release of PTX from PTX/SPIO-SSL and PTX-SSL was almost identical at both pH 6.8 and 7.4. In conclusion, the PTX/SPIO-SSL were prepared and characterized in vitro. The anti-tumor and diagnostic activity of PTX/SPIO-SSL should be investigated deeply in future study.

关 键 词：PACLITAXEL Super-paramagnetic iron oxide nanoparticles  Sterically stabilized liposomes  THERANOSTICS

分 类 号：R943]