文献类型：期刊文章

作　　者：卢艳花[1] 张臻[2] 施国新[1] 孟军才[2] 谭仁祥[2]

机构地区：[1]南京师范大学江苏省资源生物技术重点实验室,南京210097 [2]南京大学功能生物分子研究所,南京210093

出　　处：《Acta Botanica Sinica》

年　　份：2002

卷　　号：44

期　　号：6

起止页码：743-745

语　　种：中文

收录情况：CSCD、CSCD2011_2012、SCI-EXPANDED(收录号：WOS:000176695300019)、SCOPUS、WOS、普通刊

摘　　要：In addition to six known flavonoids quercitrin, hyperoside, avicularin, rutin, quercetin and kaemferol, a new flavonol glycoside named 6″_O_acetyl quercetin 3_O_β_ D _alloside (1) was isolated from the aerial parts of Hypericum perforatum L. The structures were determined on the basis of spectroscopic methods (UV, IR, FAB_MS, 1H_NMR and 13 C NMR). Antifungal assay of all compounds showed that metabolite 1, quercitrin and quercetin were inhibitory to the growth of phytopathogenic fungus Helminthosporium sativum Pamel King et Bakke with minimum inhibitory concentrations (MICs) of 25, 50 and 50 μg/mL, respectively. Moreover, glycoside 1 and quercitrin were also shown to be able to inhibit the growth of Fusarium graminearum Schw. with MIC of 100 μg/mL. The MICs of ketoconazole used as control against the test fungi were 0.5 μg/mL in our assay.

关 键 词：Hypericum perforatum  FLAVONOIDS 6″_O_acetyl quercetin 3_O_β_ D _alloside  ANTIFUNGAL

分 类 号：R284[中药学类]