文献类型：期刊文章

作　　者：韩济生[1]

机构地区：[1]北京大学神经科学研究所,北京100083

出　　处：《针刺研究》

年　　份：2001

卷　　号：26

期　　号：3

起止页码：224-225

语　　种：中文

收录情况：CAS、CSCD、CSCD2011_2012、EMBASE、IC、JST、PUBMED、RCCSE、SCOPUS、ZGKJHX、普通刊

摘　　要：Our previous studies have shown that analgesia induced by electroacupuncture (EA ) of different frequencies is mediated by different kinds of Opioid peptides. Th us, low frequency (2 Hz) EA increases the release of enkepahlins (ENK) and beta endorphin (END) in the central nervous system, whereas high frequency EA (100 Hz) increases the release of dynorphin (DYN) in the spinal cord. In recent years , ne w experiments have yielded new data that further substantiate the hypothesis put forward several years ago. 1. How to accelerate the release of endomorphin (EM) in the central nervous syst em EM is an endogenously produced morphine like peptide composed of 4 amino aci ds, showing a high specificity to mu Opioid receptor. Han et al (1999) have show n that intrathecal injection of anti EM antibody to the rat spinal cord blocked 2 Hz but not 100 Hz EA induced analgesia. Likewise, intracerebroventricular (IC V) injection of anti EM antibody or the mu receptor blocker CTOP attenuated 2 H z but not 100 Hz EA induced analgesia (Huang et al, 2000). The results suggest tha t 2 Hz EA accelerated the release of EM in brain and spinal cord to interact wit h mu Opioid receptor to produce analgesic effect. High frequency EA was not effec tive. 2. How to activate both neural pathways mediating both low and high frequency EA effect Pharmacological studies have shown that intrathecal injection of both enkepah lin and dynorphin produces a synergistic analgesic effect. It would naturally l ead to the supposition that EA analgesia may be potentiated if one could activat e both pathways simultaneously. Two paradigms could be used. Paradigm A is to us e low frequency (LF) and high frequency (HF) alternatively, each lasting for a c ertain period (already optimized to be 3 sec). Paradigm B is to use LF in one li mb and HF in another limb. Pharmacological studies were used to analyze the recept or mechanisms; neurochemical detection and antibody microinjection technique wer e used to identify the neuropeptides responsible for producing the

关 键 词：针刺 镇痛 电针 神经肽 中枢神经

分 类 号：R245－0] R338.3]