文献类型：期刊文章

作　　者：熊盛[1] 林剑[2] 姚汝华[1] 宗敏华[1]

机构地区：[1]华南理工大学生物工程系,广东广州510640 [2]暨南大学生物工程研究所,广东广州510632

出　　处：《中国病理生理杂志》

基　　金：国家"九五"科技攻关重点项目 (No .96-C0 2- 0 1- 0 3 )

年　　份：2002

卷　　号：18

期　　号：2

起止页码：214-217

语　　种：中文

收录情况：BDHX、BDHX2000、CAS、CSCD、CSCD2011_2012、JST、RCCSE、ZGKJHX、核心刊

摘　　要：Basic fibroblast growth factor (bFGF) is a multi-potential growth factor whose biological activities depend on its receptor’s intrinsic tyrosine kinase activity and second messengers such as the mitogen activated protein kinases. Heparin sulfate proteoglycans (HSPGs) have been demonstrated to enhance or inhibit bFGF activity. The response elicited by HSPG is related to the relative concentrations and binding kinetics for bFGF of the various pools of HSPG. The type of cellular response might depend on the specific HSPG and FGF receptor expressed on the cell surface. The specific core protein of HSPG, and tissue specific differences in heparin sulfate modification result in altered bFGF regulation.

关 键 词：碱性成纤维细胞生长因子 肝素 结合性质  

分 类 号：R91[药学类]