文献类型：期刊文章

作　　者：申元英[1] 杨占秋[2] 刘建军[2] 肖红[2] 郭广松[3]

机构地区：[1]云南大理医学院微生物教研室,云南大理671000 [2]武汉大学医学院病毒研究所,湖北武汉430071 [3]武汉大学医学院附属第二临床医院病理科,湖北武汉430071

出　　处：《中国病毒学》

基　　金：湖北省教委项目! ( 98A0 5 1)

年　　份：2001

卷　　号：16

期　　号：1

起止页码：85-87

语　　种：中文

收录情况：CSCD、CSCD2011_2012、普通刊

摘　　要：In order to search a effective therapy for viral myocarditis, antivial activity of Rheum officinale on Coxsackieivirus B 3 (CVB 3) was evaluated in BALB/C mice. After being determined optium scheme with orthogonal design, mice infected with CVB 3 were treated with Rheum officinale , ribavirin and 0.9% NaCl. The survival rates of the mice were 35%,5% and 5%;Median survival time were 23,11 and 10.5 days;Infectious viral titers were 10 -3.2 ,10 -4.7 and 10 -4.7 TCID 50 / 0.1 mL repectively, The lesions of cardiac tissues lightened in mice treated with Rheum offinicale . These results showed that Rheum officinale was effective in treatment of CVB 3 infected mice. The study provided scientific basis for further research and widen antiviral spectrum of Rheum officinale .

关 键 词：大黄  柯萨奇病毒B3 病毒性心肌炎 BALB/C鼠 肠道病毒

分 类 号：R373]