文献类型：期刊文章

作　　者：钟鸣[1,2,3] 崔希凯[2,3] 孟祥豹[2,3] 李中军[2,3]

机构地区：[1]韶关大学医学院药学系,广东韶关512026 [2]北京大学医学部天然药物与仿生药物国家重点实验室 [3]药学院化学生物学系,北京100191

出　　处：《Journal of Chinese Pharmaceutical Sciences》

基　　金：National Natural Science Foundation of China(NSFC,Grant No.21072017)

年　　份：2013

卷　　号：22

期　　号：2

起止页码：144-147

语　　种：中文

收录情况：CAB、CAS、CSCD、CSCD2013_2014、DOAJ、EMBASE、IC、JST、SCOPUS、ZGKJHX、普通刊

摘　　要：Using the potent anticancer agent 2-deoxy-2-chloro-1-amino sugar as a lead compound, its analogs were prepared in 6 steps starting from D-glucal. The key step was the synthesis of 2-chloro-1-acetamido sugars using （COCl） 2-AgNO 3-CH 3 CN system in high yields. 2-Deoxy-2-chloro-1-amino sugars were obtained by treating the corresponding acetamido sugars with HCl in MeOH. All the compounds, including the reference compound, displayed almost no cytotoxic activity to the selected cancer cell lines.

关 键 词：2-Deoxy-2-chloro-1-amino sugars Cytotoxic activity Epimer  

分 类 号：R96] R914[药学类]