文献类型：期刊文章

作　　者：史天星[1] 李宇光[2] 姜勇[1] 屠鹏飞[1]

机构地区：[1]北京大学医学部药学院天然药物及仿生药物国家重点实验室,北京100191 [2]辽宁省辽河油田总医院神经外科,辽宁盘锦124010

出　　处：《Journal of Chinese Pharmaceutical Sciences》

基　　金：New-Century Talent Program, Ministry of Education of China (Grant No.985-2-102-113);National Science Fund for Excellent Young Scholars (Grant No. 81222051);National Key Technology R&D Program "New Drug Innovation" of China (Grant No. 2012ZX09304-005, 2012ZX09301002-002)

年　　份：2013

卷　　号：22

期　　号：1

起止页码：36-39

语　　种：中文

收录情况：CAB、CAS、CSCD、CSCD2013_2014、DOAJ、EMBASE、IC、JST、SCOPUS、ZGKJHX、普通刊

摘　　要：The aim of this study was to isolate the chemical constituents of the aerial parts of Polygala tenuifolia Willd. and to determine their antioxidant activities. Ten flavonoids were isolated and purified by silica gel, Sephadex LH-20, and ODS column chromatography, and semi-preparative HPLC. Their structures were elucidated by spectroscopic analysis and identified as isorhamnetin-3-O-13-D-glucopyranoside （1）, isorhamnetin-3-O-13-D-galactopyranoside （2）, quercetin-3-O-13-o-glucopyranosyl （1--＊2）-I^-D-galactopyranoside （3）, quercetin-3-O-13-O-glucopyranosyl （1---~2）-13-D-glucopyranoside （4）, linarin （5）, quercetin-3-O- 13-D-glucopyranoside （6）, 5,7-dihydroxy-8-methxoyflavone-7-O-13-o-glucuronoside （7）, isorhamnetin （8）, kaempferol （9） and quercetin （10）. All these compounds were isolated from this plant for the first time, and compounds 1-5 and 7 were isolated from the genus of Polygala for the first time. The antioxidant activities of the isolated compounds were evaluated by DPPH free radical scavenging assay, and compounds 3, 4, 6, 8, 9 and 10 showed potent antioxidant activities.

关 键 词：POLYGALA Polygala tenuifolia  Aerial parts  FLAVONOIDS Antioxidant activity  

分 类 号：R284.2[中药学类]