文献类型：期刊文章

作　　者：李剑勇[1,2] 唐峰[3] 周绪正[1,2] 张继瑜[1,2] 牛建荣[1,2] 魏小娟[1,2] 杨亚军[1,2]

机构地区：[1]中国农业科学院兰州畜牧与兽药研究所,甘肃兰州730050 [2]中国农业科学院新兽药工程重点实验室,甘肃兰州730050 [3]辽宁医学院畜牧兽医学院,辽宁锦州121000

出　　处：《Animal Husbandry and Feed Science》

基　　金：中国农业科学院科研基金项目(20041001)~~

年　　份：2009

卷　　号：1

期　　号：3

起止页码：36-39

语　　种：中文

收录情况：CAB、CAS、CSA、PROQUEST、外刊、普通刊

摘　　要：[Objective] The paper presents the pharmacokinetics of Junmie in healthy rabbits and thus provides a basis for its rational application. [ Method] HPLC method was developed to detect the concentration of Junmie with benzoyl ciprofloxacin as internal standard. After the healthy rab bits was respectively injected Junmie intravenously and intramuscularly, plasma concentration after injection was detected with the established HPLC method so as to determine the best pharmacokinetic model. [Result] The conditions of HPLC were as follows： mobile phase was 100 ml 60% （V/V） methanol solution （pH 3.0） ; flow rate was 1.0 mVmin; column temperature was （25.0 ±0.5） ℃; detection wavelength was 278 nm. The concentration time data of the plasma, collected from intravenously and intramuscularly injected rabbits, was separately in line with the two com partments and one compartment open model with the first order absorption. The main pharmacokinetic parameters of the plasma sample （ i. v. ） were as below： T1/2= = 0.07 h, T1/2 = 0.82 h, AUC = 3.51 mg/（L . h）, CLB = 4.57 L/（kg . h） ; the plasma sample （i. m. ） ： T1/2 = 0.33 h, T1/2k = 0.33 h, Tp = 0.6 h, Cmax = 2.55 μg/ml, AUC = 4.87 mg/（L . h）. The bioavailability was approximately 110%. [Conclusion] After intra muscular administration, Junmie is absorbed and eliminated quickly with high bioavallability and extensive distribution.

关 键 词：Junmie  HPLC PHARMACOKINETICS RABBITS

分 类 号：S859.79]