文献类型：期刊文章

作　　者：朱慧[1,2] 成聪[1] 张弛[1] 王钊[1]

机构地区：[1]清华大学医学院生物科学与技术系蛋白质科学教育部重点实验室,北京100084 [2]北京市结核病胸部肿瘤研究所药物研究室,北京101149

出　　处：《Journal of Chinese Pharmaceutical Sciences》

基　　金：National Basic Research Program(973 Project) of China(Grant No.2007CB507406);the National Natural Science Foundation of China(Grant No.30572341);the Tsinghua-Yue-Yuen Medical Sciences Fund(THYY20070008)

年　　份：2011

卷　　号：20

期　　号：5

起止页码：523-528

语　　种：中文

收录情况：CAB、CAS、DOAJ、EMBASE、IC、JST、SCOPUS、ZGKJHX、普通刊

摘　　要：Echinacoside is one of the phenylethanoids isolated from the stems of Cistanches salsa. Our previous research showed that echinacoside has anti-senescence activity. To investigate the mechanism of echinacoside＇s anti-senescence activity, the expressions of p53, p21, p16 and Rb at the mRNA and protein levels were determined. Results showed that the expression of p53 was down-regulated significantly in a dose dependent manner after treatment with echinacoside. Further experiments suggested that the down-regulation of p53 may be correlated with the upregulation of SIRT1. In addition, echinacoside may exhibit considerable higher affinity towards SIRT1 than resveratrol, according to our molecular docking simulation. In conclusion, we expect that echinacoside might be a promising candidate for regulating cell senescence.

关 键 词：ECHINACOSIDE Cellular senescence  P53 SIRT1

分 类 号：R285.5[中药学类]