文献类型：期刊文章

作　　者：郭洁[1] 徐嵬[1] 杨秀伟[1]

机构地区：[1]北京大学医学部天然药物及仿生药物国家重点实验室药学院天然药物学系,北京100191

出　　处：《Journal of Chinese Pharmaceutical Sciences》

基　　金："Major New Medicine Project"in National Science and Technology Major Project of China(Grant No.2009ZX09301-010)

年　　份：2011

卷　　号：20

期　　号：5

起止页码：505-509

语　　种：中文

收录情况：CAB、CAS、DOAJ、EMBASE、IC、JST、SCOPUS、ZGKJHX、普通刊

摘　　要：The intestinal permeability of three sesquiterpene lactones, atractylenolide Ⅰ, Ⅱ, and Ⅲ, was investigated using the human Caco-2 cell monolayer model. The bidirectional permeability of the three compounds from the apical （AP） to the basolateral （BL） side and in the reserved direction was studied. The three compounds were assayed using HPLC. The Papp values of atractylenolide Ⅰ, Ⅱ, and Ⅲ were all at the level of 10^-5 cm/s, suggesting high intestinal permeability and good absorption. The bidirectional transport of the three compounds was time- and concentration-dependent, and indicated the main mechanism of the passive diffusion of the three compounds across the intestinal epithelium membrane. Moreover, atractylenolide Ⅰ might be partly actively transported.

关 键 词：Atractylenolide Ⅰ  Atractylenolide Ⅱ  Atractylenolide Ⅲ  Caco-2 cell monolayer model  Intestinal permeability  

分 类 号：R285[中药学类]