文献类型：期刊文章

作　　者：韩德五[1] 赵龙凤[1]

机构地区：[1]山西医科大学肝病研究所,太原030001

出　　处：《基础医学与临床》

年　　份：1999

卷　　号：19

期　　号：6

起止页码：2-7

语　　种：中文

收录情况：CSCD、CSCD2011_2012、JST、ZGKJHX、普通刊

摘　　要：It thas been reported that the various experimental liver injuries and patients with liver diseases are accompanied by intestinal endotoxemia (IETM). Up to now, the effect of IETM on the chronicity of hepatitis, its pervention and treatment have received little attention.According to the study of a large number of animal experiments and clinics, we raise a new conception of the pathogenesis of hepatic injury in hepatitis:The various factors induce liver injury(for example,hepatic virus, alcohol, medicines and hepatotoxic agents and so on )by various specific mechanisms,which is called "The primary liver injury ". IETM is occurred in the deveopment of hepatitis. Endotoxin activated kupffer cells and produced a number of chemical mediators. The liver injury caused by mediators is called"The secondary liver injury". This "The secondary liver injury" depends on serious degree of IETM. The repeated and persistent hepatocellular necrosis in light IETM condition accompanying hepatocellular regeneration and inflammatory cells infiltration develop the chronic hepatitis and/or liver fibrosis, even cirrhosis and hepatocarcinoma. The severe IETM offen leads to overinflammation following serious hepatocellular necrosis, even grows up severe hepatitis, liver failure further is appeared.

关 键 词：肝炎 肠源性 内毒素血症

分 类 号：R512.6]