文献类型：期刊文章

作　　者：张力勤[1] 黄应栋[1] 杨秀伟[1]

机构地区：[1]北京大学医学部天然药物及仿生药物国家重点实验室药学院天然药物学系,北京100191

出　　处：《Journal of Chinese Pharmaceutical Sciences》

基　　金：National New Drug R & D Program(Grant No. 2009ZX09301-010);National High Technology Program(Grant No. 2002AA2Z343C,2004AA2Z3783) of China;Ability Enhancing Project of National Science Fund for Talent Training in Basic Science(Grant No.J0830836)

年　　份：2010

卷　　号：19

期　　号：6

起止页码：451-458

语　　种：中文

收录情况：CAB、CAS、DOAJ、EMBASE、IC、JST、SCOPUS、ZGKJHX、普通刊

摘　　要：The intestinal permeability of two flavonoid compounds liquiritin （LQ） and isoliquiritin （ILQ） was investigated using the Caco-2 cell monolayer model. In order to evaluate the permeability and predict the absorption mechanism of the two compounds, the study on bidirectional permeability from the apical （AP） side to the basolateral （BL） side as well as from the BL side to the AP side was carried out. The determination was performed by HPLC-UV method. And the permeability parameters, especially the apparent permeability coefficients （Papp）, were then calculated. The Papp values of LQ and ILQ are （5.40±0.16）× 10^-7 and （8.69±0.15）× 10^-7 cm/s, respectively. The results of time- and concentration-dependent transport experiments indicate that both LQ and ILQ are poor absorbed mainly through passive diffusion.

关 键 词：LIQUIRITIN ISOLIQUIRITIN Caco-2 cell monolayer model  Intestinal permeability  

分 类 号：R285[中药学类]