文献类型：期刊文章

作　　者：郑愉[1] 孟祥豹[1] 李树春[1] 黄河清[1] 李中军[1] 李庆[1]

机构地区：[1]北京大学医学部天然药物及仿生药物国家重点实验室药学院化学生物学系,北京100191

出　　处：《Journal of Chinese Pharmaceutical Sciences》

基　　金：National Natural Science Foundation of China (Grant No.20732001,90713004)

年　　份：2010

卷　　号：19

期　　号：5

起止页码：327-340

语　　种：中文

收录情况：CAB、CAS、DOAJ、EMBASE、IC、JST、SCOPUS、ZGKJHX、普通刊

摘　　要：Novel prodrugs of cyclophosphamide 1a and 1b, which comprised the galactosyl moiety, the key fraction of cyclophosphamide derivates, and the linker 4-hydroxy benzaldehyde, were synthesized. These compounds were anticipated to exhibit amplified anti-tumor activity and targeting ability.

关 键 词：CYCLOPHOSPHAMIDE GALACTOSIDE Hepatocyte targeting  ANTI-TUMOR

分 类 号：R914] R96[药学类]