文献类型：期刊文章

作　　者：厉蔚[1] 李庆娇[1] 安书成[1]

机构地区：[1]陕西师范大学生命科学学院,脑与行为科学研究所,西安710062

出　　处：《Neuroscience Bulletin》

基　　金：supported by the Natural Science Foundation of Shaanxi Province, China (No.2006C240)

年　　份：2010

卷　　号：26

期　　号：2

起止页码：140-146

语　　种：中文

收录情况：CAS、CSCD、CSCD2011_2012、EBSCO、EMBASE、IC、JST、PUBMED、SCI(收录号：WOS:000295723700006)、SCI-EXPANDED(收录号：WOS:000295723700006)、SCIE、SCOPUS、SSCI(收录号：WOS:000295723700006)、WOS、ZGKJHX、普通刊

摘　　要：Objective To investigate the roles of estrogen and kalirin-7 in chronic restraint stress （CRS）-induced depression and the pathophysiological mechanism of depression. Methods Healthy female mice from Institute of Cancer Research （ICR） were randomly divided into 3 groups： control group, CRS group, and estrogen ＋ CRS group. CRS was used to establish the animal model of depression. Forced swimming test and immunohistochemistry method were utilized to investigate the animal behavior and kalirin-7 expression in the hippocampus, respectively. Results Compared with the control group, the CRS mice displayed depression-like behaviors, including a significant reduction in body weight, a significant increase in immobility time in forced swimming test, and a dramatic decrease in kalirin-7 expression in the hippocampus. However, administration of estrogen attenuated the CRS-induced negative behaviors, and simultaneously increased kalirin-7 expression. Conclusion Estrogen replacement therapy （ERT） could prevent CRS-induced depression-like behaviors in female ICR mice. Besides, kalirin-7 also plays a role in preventing CRS-induced depression-like behaviors.

关 键 词：chronic restraint stress  DEPRESSION ESTROGEN neural plasticity  kalirin-7  

分 类 号：R749.4]