文献类型：期刊文章

作　　者：王耀晟[1,2] 程晓曙[1,2]

机构地区：[1]南昌大学第二附属医院心血管内科 [2]南昌大学医学院心血管病研究所,江西南昌330006

出　　处：《中国病理生理杂志》

基　　金："十一五"国家科技支撑计划资助项目(No.2008BA1681300)

年　　份：2009

卷　　号：25

期　　号：12

起止页码：2483-2486

语　　种：中文

收录情况：BDHX、BDHX2008、CAS、CSCD、CSCD2011_2012、JST、RCCSE、ZGKJHX、核心刊

摘　　要：Integrin-linked kinase (ILK) is a widely expressed protein kinase that relate to cellular growth and differentiation. It is most abundant in the heart. Recently,many researches revealed that ILK is highly relevant to cardiac response to biomechanical stresses. Also,ILK plays important roles in regulation of the occurrence and development of cardiac hypertrophy,dilated cardiomyopathy,viral myocarditis and myocardial senescence via correlation to several classical signal transduction pathway. Meanwhile,ILK functions in protection after myocardial infarction. This article will try to summarize the effects and relevant mechanism of ILK in above-mentioned aspects,overall reveals the roles of ILK in heart and its potential clinical significance.

关 键 词：整合素连接激酶 心脏肥大 心肌病 充血性 心肌炎 心肌梗死  信号转导途径

分 类 号：R54]