文献类型：期刊文章

作　　者：宋志国[1] 王敏[2] 宫红[3] 姜恒[3]

机构地区：[1]渤海大学科技实验中心,辽宁锦州121000 [2]渤海大学化学化工学院,辽宁锦州121000 [3]辽宁石油化工大学,辽宁抚顺113001

出　　处：《化学研究与应用》

年　　份：2009

卷　　号：21

期　　号：11

起止页码：1597-1600

语　　种：中文

收录情况：BDHX、BDHX2008、CAS、CSCD、CSCD2011_2012、JST、RSC、ZGKJHX、核心刊

摘　　要：3,4-Dihydropyrimidin-2-(1H)-ones were synthesized in high yields by a one-pot cyclocondensation of aldehyde,1,3-dicarbonyl compound,and urea or thiourea using copper o-toluenesulfonate as a catalyst under solvent-free conditions at 90℃.Effects of molar ratio of reactants,amount of catalyst,and reaction temperature on the yields of 3,4-dihydropyrimidin-2-(1H)-ones were investigated.The results showed that at the condition of naldehyde∶n1,3-dicarbonyl compounds∶nurea(or thiourea)=1∶1.2∶1.5,1 mol% catalyst(molar percent of aldehyde),2.0 h at 90℃,the yields of products were 51-96%.After reaction,the catalyst could be reused for four times without distinct loss of catalytic activity.

关 键 词：BIGINELLI反应 3  4-二氢嘧啶-2(1H)-酮  邻甲基苯磺酸铜  一锅法

分 类 号：O626.4]