文献类型：期刊文章

作　　者：谢宇[1] 尚晓娴[1] 蒋丰兴[1] 胡金刚[1] 颜流水[1]

机构地区：[1]南昌航空大学环境与化学工程学院材料化学系,江西南昌330063

出　　处：《化学研究与应用》

基　　金：国家自然科学基金(20765003/B050106);江西省自然科学基金(0620071);江西省教育厅科技项目(赣教技字[2007]168号);航空高校科研基金(EA200502138)资助项目

年　　份：2008

卷　　号：20

期　　号：12

起止页码：1617-1621

语　　种：中文

收录情况：BDHX、BDHX2004、CAS、CSCD、CSCD2011_2012、JST、RSC、ZGKJHX、核心刊

摘　　要：The chitosan nanosphere is formed by the ion gel and charactered by TEM.The encapsulation efficiency and controlled release of chitosan nanoparticles for BSA are studied.The result suggests that the high encapsulation efficiency and loading of BSA reach 86% and 49%,the BSA encapsulation efficiency and the BSA loading are affected by the initial CS concentration and the initial BSA concentration,the higher the initial CS concentration,the higher the BSA encapsulation efficiency and the BSA loading.However,it shows opposite trend when the initial BSA concentration increase.The BSA loading increase,but the encapsulation efficiency decrease.The TPP concentration has little influence on BSA encapsulation efficiency.The behavior of chitosan nanospheres for BSA in vitro release revealed a controlled and continuous release of the entrapped protein after 12 hours and released 30% of the BSA loading within 3 hours.

关 键 词：壳聚糖 纳米微球 牛血清蛋白 包封 缓释

分 类 号：O636.1]