文献类型：期刊文章

作　　者：刘建群[1] 刘芳[2] 张小平[3] 寇晓莉[1]

机构地区：[1]江西中医学院现代中药制剂教育部重点实验室,江西南昌330004 [2]江西萍乡高等专科学校化工系,江西萍乡337055 [3]江西川奇药业有限公司,江西南昌330029

出　　处：《化学研究与应用》

基　　金：南昌市科技型中小企业技术创新基金(2007)资助项目

年　　份：2008

卷　　号：20

期　　号：11

起止页码：1498-1501

语　　种：中文

收录情况：BDHX、BDHX2004、CAS、CSCD、CSCD2011_2012、JST、RSC、ZGKJHX、核心刊

摘　　要：2-Acetamidoacrylic acid or methyl 2-acetamidoacrylate is reacted with solution of sodium of methylselenol to give N-acetyl-Se-methylselenocysteine.The L(and D)-Se-methylselenocysteine have been prepared in high optical purity by treating N-acetyl-Se-methylselenocysteine in water using acylase I from porcine kidney as a catalyst.The influencing factors on the resolution reaction are discussed by orthogonal experiment,including pH value,reaction temperature,concentration of Co2+ and amount of acylase I.Under the optimizing resolution conditions,L(and D)-Se-methylselenocysteine are obtained with>96 % optical purity in about 40% yield.

关 键 词：硒-甲基硒代半胱氨酸  2-乙酰氨基丙烯酸  2-乙酰氨基丙烯酸甲酯  合成  拆分

分 类 号：O627.6]