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期刊文章详细信息

金属离子介导下的紫杉醇与血清蛋白结合反应机制的研究    

Study on the interaction between paclitaxel-iron(Ⅲ) and bovine serum albumin

  

文献类型:期刊文章

作  者:郭明[1] 王炜[1] 周建钟[1] 郭晓勤[1]

机构地区:[1]浙江林学院理学院化学系,浙江临安311300

出  处:《化学研究与应用》

年  份:2008

卷  号:20

期  号:4

起止页码:457-460

语  种:中文

收录情况:BDHX、BDHX2004、CAS、CSCD、CSCD2011_2012、JST、RSC、ZGKJHX、核心刊

摘  要:In view of the influence by Fe3+,the reaction between paclitaxel and bovine serum albumin(BSA) in aqueous solution was studied by fluorescence spectroscopy and ultraviolet spectra.The binding constant K and the binding sites n were measured according to suggested model. The binding distance r and transfer efficiency E between paclitaxel-iron(Ⅲ) and BSA were also obtained according to Fōrster theory of non-radiative energy transfer.The results indicated that there is a stronger binding force between paclitaxel-iron(Ⅲ) and BSA.

关 键 词:紫杉醇 牛血清白蛋白 荧光光谱 紫外光谱

分 类 号:O643.12]

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