期刊文章详细信息
金属离子介导下的紫杉醇与血清蛋白结合反应机制的研究
Study on the interaction between paclitaxel-iron(Ⅲ) and bovine serum albumin
文献类型:期刊文章
机构地区:[1]浙江林学院理学院化学系,浙江临安311300
年 份:2008
卷 号:20
期 号:4
起止页码:457-460
语 种:中文
收录情况:BDHX、BDHX2004、CAS、CSCD、CSCD2011_2012、JST、RSC、ZGKJHX、核心刊
摘 要:In view of the influence by Fe3+,the reaction between paclitaxel and bovine serum albumin(BSA) in aqueous solution was studied by fluorescence spectroscopy and ultraviolet spectra.The binding constant K and the binding sites n were measured according to suggested model. The binding distance r and transfer efficiency E between paclitaxel-iron(Ⅲ) and BSA were also obtained according to Fōrster theory of non-radiative energy transfer.The results indicated that there is a stronger binding force between paclitaxel-iron(Ⅲ) and BSA.
关 键 词:紫杉醇 牛血清白蛋白 荧光光谱 紫外光谱
分 类 号:O643.12]
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