文献类型：期刊文章

作　　者：刘畅[1] 金丹婷[1] 钟梁[1] 袁佩[2] 刘北忠[1] 王东生[1] 王翀[1] 郝坡[1]

机构地区：[1]重庆医科大学医学检验系省部共建教育部重点实验室,重庆400016 [2]重庆医科大学医药研究所,重庆400016

出　　处：《化学研究与应用》

基　　金：国家自然科学基金(30300449)资助项目;国家中医药管理局(02-03ZP52)资助项目

年　　份：2008

卷　　号：20

期　　号：3

起止页码：341-344

语　　种：中文

收录情况：BDHX、BDHX2004、CAS、CSCD、CSCD2011_2012、JST、RSC、ZGKJHX、核心刊

摘　　要：A new dexamethasone derivative of 9-fluoro-16α-methyl-11,17-dihydroxy-3-oxo-1,4-androsladiene-17β-carboxylic acid from dexamethasone is synthesized by oxidization with periodic acid. The physicochemical property of the new derivative is identified with routine methods. Its structure is characterized by 1H NMR,13C NMR and ESI-MS spectra. The effect of the new derivative on K562 cell proliferation was detected by MTT, as well as the cell cycle by flow cytometry.The result show that the dexamethasone derivative had anti-tumor activities of K562 cell proliferation inhibition and cell cycle arresting from G0/G1 to S phase.

关 键 词：地塞米松衍生物  合成  抗肿瘤活性

分 类 号：O629.2]