文献类型：期刊文章

作　　者：潘攀[1] 陈桂辉[1] 陈颖[1] 孟祥豹[1] 李中军[1] 崔景荣[1]

机构地区：[1]北京大学药学院化学生物学系,天然药物及仿生药物国家重点实验室,北京100083

出　　处：《Journal of Chinese Pharmaceutical Sciences》

基　　金：The National Basic Research Program(973Program,Grant No.2004CB518904).

年　　份：2007

卷　　号：16

期　　号：4

起止页码：272-276

语　　种：中文

收录情况：CAB、CAS、DOAJ、EMBASE、IC、JST、SCOPUS、ZGKJHX、普通刊

摘　　要：Aim To develop a novel selective protection strategy for the synthesis of ribostamycin cyclic carbamate derivatives. Methods Ribostamycin protected by carbobenzoxy group was treated with Nail, to give different protected intermediates under respective controllable cyclization reaction conditions. New ribostamycin derivative was obtained after the cleavage of carbobenzoxy groups. Result The novel selective protection of ribostamycin was achieved by the synthesis of protected intermediates. New ribostamycin derivative was obtained, but showed no expected antibacterial activity. Conclusion Several ribostamycin cyclic carbamate derivatives were obtained by novel selective protection strategy, which shows the practicability and convenience of the protection strategy. But these new ribostamycin derivatives containing cyclic carbamates structure may not be an ideal leading compound for antibiotic activity.

关 键 词：AMINOGLYCOSIDE Ribostamycin  Cyclic carbamate  SELECTIVITY DERIVATIVES

分 类 号：R96]