文献类型：期刊文章

作　　者：Mohammed AL-JUMAILY[1] Alexei KOZLENKOV[1] Ilana MECHALY[1] Agnes FICHARD[1] Valerie MATHA[1] Frederique SCAMPS[1] Jean VALMIER[1] Patrick CARROLL[1]

机构地区：[1]法国国家健康与医学研究院

出　　处：《Neuroscience Bulletin》

年　　份：2007

卷　　号：23

期　　号：5

起止页码：293-299

语　　种：中文

收录情况：CAS、CSCD、CSCD2011_2012、EBSCO、EMBASE、IC、JST、PUBMED、SCI、SCIE、SCOPUS、WOS、ZGKJHX、普通刊

摘　　要：Objective A calcium-activated chloride current （ICl（Ca）） has been observed in medium-sized sensory neurons of the dorsal root ganglion （DRG）. Axotomy of the sciatic nerve induces a similar current in the majority of medium and large diameter neurons. Our aim is to identify the molecule（s） underlying this current. Methods Using conventional and quantitative RT-PCR, we examined the expression in DRG of members of three families of genes, which have been shown to have latch） current inducing properties. Results We showed the detection of transcripts representing several members of these families, i.e. chloride channel calciumactivated （CLCA）, Bestrophin and Tweety gene families in adult DRG, in the normal state and 3 d after sciatic nerve section, a model for peripheral nerve injury. Conclusion Our analysis revealed that that mBestl and Tweety2 appear as the best candidates to play a role in the injury-induced Icl（Ca） in DRG neurons.

关 键 词：chloride channel calcium activated  BESTROPHIN tweety  chloride channel  dorsal root ganglion  

分 类 号：Q42]