文献类型：期刊文章

作　　者：王陆军[1] 岳鹏飞[1] 赵艳玲[1] 蔡培烈[2] 周旭[1] 袁海龙[1]

机构地区：[1]中国人民解放军第302医院全军中药研究所,北京100039 [2]汇仁集团,上海201203

出　　处：《Journal of Chinese Pharmaceutical Sciences》

年　　份：2007

卷　　号：16

期　　号：2

起止页码：146-152

语　　种：中文

收录情况：CAB、CAS、DOAJ、EMBASE、IC、JST、SCOPUS、ZGKJHX、普通刊

摘　　要：Aim The oxymatrine phospholipid complexs were prepared, and its activity against hepatitis B virus in vitro were studied. Methods Using tetrahydrofuran as a reaction medium, oxymatrine and phospholipids were resolved into the medium, Oxymatrine phospholipid eomplexs were prepared. The toxicity measurements and inhibitory effect on HBsAg, HBeAg, and HBVDNA of oxymatrine phospholipid complex in 2.2.15 cells were studied respectively. Results The content of oxymatrine in the phospholipids eomplexs prepared was 24,86% （W/W）. The TCO of the oxymatrine phospholipid eomplexs was 250 μmol·L^- 1 The inhibitory effect of HBsAg, HBeAg, HBV-DNA of 2.2.15 cells treated by oxymatrine phospholipid complex were higher than those of the oxymatrine. Conclusion Oxymatrine phospholipid complex can have stronger effective activity against hepatitis B virus compared with oxymatrine. So oxymatrine phospholipid eomplexs were showing its potential antiviral activity in hepatitis B treatment.

关 键 词：Oxymatrine phospholipid complex  2.2.15 Cell line  HBV-DNA

分 类 号：R943] R96[药学类]