文献类型：期刊文章

作　　者：杨艳[1] 金永生[1] 董真秀[1] 胡宏岗[1] 俞世冲[1] 吴秋业[1]

机构地区：[1]第二军医大学药学院有机化学教研室,上海200433

出　　处：《高等学校化学学报》

年　　份：2007

卷　　号：28

期　　号：7

起止页码：1310-1312

语　　种：中文

收录情况：AJ、BDHX、BDHX2004、CAS、CSCD、CSCD2011_2012、EI(收录号：20073210755469)、IC、JST、RCCSE、RSC、SCIE、SCOPUS、WOS、ZGKJHX、核心刊

摘　　要：Capsaicin and(E)-4-hydroxy-3-methoxybenzyl-8-methylnon-6-enoate were important intermediate of medicine.This research proposed a new method for synthesizing them from 6-bromohexanoic ester by Wittig reaction to give(Z)-8-methyl-6-nonenoic acid(4),then treated by nitrous acid and NaNO2 to induce Z→E isomerization reaction of the carbon-carbon double bond,then followed by condensation reaction to give product in an overall yield of 31%.The method is more convenient than traditional methods.

关 键 词：辣椒素 8-甲基-E-6-壬烯酸(4′-羟基-3′-甲氧基)苄酯  WITTIG反应

分 类 号：O621]