文献类型：期刊文章

作　　者：孟祥豹[1] 李妍萍[1] 李中军[1]

机构地区：[1]北京大学药学院化学生物学系天然药物与仿生药物国家重点实验室,北京100083

出　　处：《Journal of Chinese Pharmaceutical Sciences》

基　　金：We thank the National Science Foundation of China(NSFC,N0.20372003)for financial support.

年　　份：2007

卷　　号：16

期　　号：1

起止页码：43-46

语　　种：中文

收录情况：CAB、CAS、DOAJ、EMBASE、IC、JST、SCOPUS、ZGKJHX、普通刊

摘　　要：Aim To develop a concise method for the synthesis of bicyclic azasugar and thiosugar with novel scaffold. Methods The two primary hydroxyl groups of compound 1 were selectively protected with tosyl cloloride in pyridine, followed by ring-closure with sodium sulfide or primary amine to form the oxy-bridged bicyclic molecules in good yields. Results Two bicyclic azasugars and a thiosugar were produced from L-sorbose in several steps. Conclusion The described procedures provide an efficient method to synthesize bicyclic azasugar and thiosugar with novel scaffold as potential glycosidase inhibitors.

关 键 词：Oxy-bridge  Bicyclic azasugar  Bicyclic thiosugar  RING-CLOSURE

分 类 号：R914]