文献类型：期刊文章

作　　者：靳淼[1] 樊景凤[2] 于天飞[1] 方肇寅[3] 王君伟[1]

机构地区：[1]东北农业大学动物医学院预防兽医学系,哈尔滨150030 [2]国家海洋环境监测中心,大连116023 [3]中国疾病预防控制中心病毒病预防控制所,北京100052

出　　处：《病毒学报》

基　　金：国家863课题(课题编号:2002A639470)

年　　份：2007

卷　　号：23

期　　号：1

起止页码：63-67

语　　种：中文

收录情况：BDHX、BDHX2004、BIOSISPREVIEWS、CAB、CAS、CSCD、CSCD2011_2012、IC、JST、PUBMED、RCCSE、SCOPUS、WOS、ZGKJHX、核心刊

摘　　要：Sequence analysis of a new norovirus(NV) isolated from Lanzou city of China was performed based on partial sequence of RNA dependent RNA polymerase(RdRp) and complete capsid protein(VP1) gene.The isolated strain CHN02/LZ35666 shared high sequence homology with GII-4 NVs.Nucleotide homologies of RdRp region and encoded capsid protein region were 90.4%-98.6% and 89.8%-95.7%,respectively,while amino acid homology of capsid protein region was 94.4%-97.4%.The analysis of GDD motif in RdRp region indicated this GDD motif of Lanzhou strain differed from those of the GII-4 predominant epidemic strains.Lanzhou strain formed an independent branch in GII-4 cluster in the phylogenetic tree based on nucleotide sequence of RdRp region and amino acid sequence of capsid protein.Sequence alignment revealed a mutation at the fourth key site of the receptor-binding interface in the strains isolated after 2002 compared with those of previous strains suggesting a possible change of binding pattern to HBGAs receptors.

关 键 词：诺如病毒 病毒性胃肠炎 RDRP 衣壳蛋白 序列分析  

分 类 号：Q78]