文献类型：期刊文章

作　　者：朱海波[1] 王振华[2] 田京伟[2] 傅风华[2] 刘坷[2] 李长龄[3]

机构地区：[1]中国医学科学院中国协和医科大学药物研究所,北京100050 [2]烟台大学药学院,山东烟台264003 [3]北京大学医学部药学院,北京100083

出　　处：《药学学报》

基　　金：国家自然科学基金资助项目(30370720);国家高技术研究发展计划(863计划)资助项目(2004AA2Z3815).

年　　份：2005

卷　　号：40

期　　号：12

起止页码：1144-1146

语　　种：中文

收录情况：AJ、BDHX、BDHX2004、BIOSISPREVIEWS、CAB、CAS、CSCD、CSCD2011_2012、DOAJ、EMBASE、IC、IPA、JST、PUBMED、RCCSE、RSC、SCOPUS、WOS、ZGKJHX、核心刊

摘　　要：Aim To investigate the protective effect of hydroxysafflor yellow A（HSYA）,a soluble element extracted from Carthamus tinctorius L.,on focal cerebral ischemia in rats.Methods Focal cerebral ischemia in male Wistar-Kyoto（WKY） rats were induced by permanent middle cerebral artery occlusion（MCAO）.Three doses of 1.5,3.0 and 6.0 mg·kg-1 of HSYA were administrated to three groups of rats,separately,via sublingular vein injection 30 min after the onset of ischemia.24 h after ischemia in rats,neurological deficit scores were evaluated and the infarction area of brain was assessed by quantitative image analysis.The in vitro neuroprotective effect of HSYA was tested in cultured fetal cortical neurons exposed to glutamate and sodium cyanide（NaCN）.Results HSYA at doses of 3.0 and 6.0(mg·kg-1) exerted significant neuroprotective effects on rats with focal cerebral ischemic injury as expressed by neurological deficit scores and reduced the infarct area as compared with saline group,and the potency of HSYA at dose of 6.0 mg·kg-1 was similar to that of 0.2 mg·kg-1 of nimodipine.In vitro studies,HSYA significantly inhibited neurons damage induced by exposure to glutamate and NaCN in cultured fetal cortical cells.Conclusion HSYA has potential neuroprotective action against focal cerebral ischemia in rats and cultured rat fetal cortical neurons as well.

关 键 词：红花 羟基红花黄色素A 局灶性脑缺血 脑保护作用

分 类 号：R282.71[中药学类] R743.31[中医学类]