文献类型：期刊文章

作　　者：范振中[1] 傅旭春[2] 王国平[3] 朱龙观[3]

机构地区：[1]大庆石油学院石油工程系,大庆163318 [2]浙江大学城市学院药学系,杭州310015 [3]浙江大学化学系,杭州310027

出　　处：《无机化学学报》

基　　金：国家自然科学基金项目(No.50073019);浙江省教育厅科研项目(No.G2040417)资助

年　　份：2005

卷　　号：21

期　　号：9

起止页码：1363-1366

语　　种：中文

收录情况：BDHX、BDHX2004、CAS、CSCD、CSCD2011_2012、IC、JST、RCCSE、RSC、SCIE、SCOPUS、WOS、ZGKJHX、核心刊

摘　　要：A new Cadmium!-Ciprofloxacin ionic compound, (HCPFX)2CdCl4·3H2O, is synthesized and its crys- tal structure is determined. The crystallography data are as follows, monoclinic, space group P21/c, a=1.01039(6) nm, b=1.39989(9) nm, c=2.82245(18) nm, β=95.765 0(10)°, V=3.972 0(4) nm3, Z=4, Dc=1.627 g·cm-3, F(000)= 1984. R1=0.0540, wR2=0.1503 (I>2σ(I)). In the title compound, four chloride ions are coordinated to the cadmi- um ion forming a slightly distorted tetrahedron. Both Ciprofloxacin and the compound were assayed against gram- positive and gram-negative bacteria by doubling dilutions method, the compound shows the same minimal in- hibitory concentration (MIC) as the Ciprofloxacin against S. Aureus, M. Lutens, E. Coli and P. Aeruginosa bacte- ria. The inhibitory effect of the two compounds on leukemia HL-60 cell line has been measured by using MTT (Methyl-Thiazol-Tetrozolium) assay method. The results indicate that the complex has very strong inhibitory effect on HL-60 cell line. CCDC: 259367.

关 键 词：镉(Ⅱ)化合物  环丙沙星 晶体结构 抗菌与抗肿瘤活性  

分 类 号：O614.81]