文献类型：期刊文章

作　　者：李正香[1] 李安良[1]

机构地区：[1]北京大学药学院药物化学系,北京100083

出　　处：《Journal of Chinese Pharmaceutical Sciences》

年　　份：2004

卷　　号：13

期　　号：4

起止页码：245-248

语　　种：中文

收录情况：CAB、CAS、DOAJ、EMBASE、IC、JST、SCOPUS、ZGKJHX、普通刊

摘　　要：To study the antifungal effect of chalcone derivatives. Methods Sixteenchalcone derivatives were synthesized and confirmed by ~1H NMR and IR spectra, and tested forantifungal activity against four common pathogenic fungi. Their structure-activity relationship isdiscussed. Results Among 16 title compounds, there were 5 new compounds, which have not beenreported before. The preliminary antifungal test showed that all title compounds exhibitedantifungal activities to a certain extent. The activity of compound 8 against Trichophyton rubrumhad a potency equal to that of fluconazole, with a MIC of 4 μg·mL^(-1) . Conclusion Sixteenchalcones were prepared and their antifungal activities against four common pathogenic fungi invitro were examined. Some of them exhibited antifungal activities to a certain extent.

关 键 词：CHALCONE antifungal agent  in vitro  

分 类 号：R914] R284.2[药学类]