文献类型：会议

作　　者：宋洪涛

作者单位：[1]南京军区福州总医院药学科 [2]福建省药学会 [3]福建省药学会药剂专业委员会

会议文献：2015年中国药物制剂大会暨中国药学会药剂专业委员会2015年学术年会暨国际释控协会中国分会2015年学术年会会议论文集

会议名称：2015年中国药物制剂大会暨中国药学会药剂专业委员会2015年学术年会暨国际释控协会中国分会2015年学术年会

会议日期：20150926

会议地点：中国浙江杭州

主办单位：中国药学会

出版日期：20150926

学会名称：中国药学会

语　　种：中文

摘　　要：Co-delivery of chemotherapeutic drug and microRNA is a promoting strategy for tumor therapy due to its synergistic effect.In our study,hydrophobic doxorubicin(DOX) and negative miR-34 a were simultaneously delivered by self-assembly micelles system(SHRss) which using poly(l-arginine)-poly(l-histidine)-stearoyl as the building unit for copolymers.The SHRss micelles possessed a low critical micelle concentration(CMC) with positive surface charges and nanoscale.In addition,it facilitated the escaping of miR-34 a from endosome and release of DOX into cell nucleus,leading to the inhibition of DU145 and PC3 androgen independent prostate cancer cells.Furthermore,co-delivery of DOX and miR-34 a by SHRss micelles passively targeted in tumor tissue and a synergistic anti-proliferative efficiency was observed compared with DOX as well as the miR-34 a treatment alone in vivo.Our results demonstrated that the SHRss micelles are promising strategy for combined therapeutic strategy of genes and hydrophobic chemotherapeutic drugs.

关 键 词：医院制剂 新医改形势 发展与思考  

分 类 号：R943]