文献类型：会议

作　　者：孙云霄

作者单位：华南灵长类研究中心

会议文献：第九届中国实验动物科学年会（2010新疆）论文集

会议名称：第九届中国实验动物科学年会（2010新疆）

会议日期：20100919

会议地点：中国新疆乌鲁木齐

主办单位：中国实验动物学会（Chinese Association for Laboratory Animal Sciences）

出版日期：20100919

学会名称：中国实验动物学会

语　　种：中文

摘　　要：This review discusses non-human primate models of experimental autoimmune encephalomyelitis(EAE), which is the fittest model for related research of multiple sclerosis(MS) disease that is a progressive neurological disorder with a high unmet need for effective treatment.These models can bridge the gap between rodent EAE models and patients. Non-human primates can offer unique models for translational research into autoimmune-mediated inflammatory disorders. This review introduces the preparation and usefulness of EAE model in nonhuman primate in recent years,and includes the mechanism of MS,choosing and applying of different monkey and antigens,immunization methods,related antigens,the use of adjuvants and clinical and pathological characteristics,etc.

关 键 词：EAE Non-human Primate  MODEL Multiple Sclerosis  

分 类 号：Q9533]