文献类型：会议

作　　者：杨琴波 崔金刚 王培伟 杜霄烨 陈瑜 张腾

作者单位：上海中医药大学附属岳阳中西医结合医院中西医结合临床研究所,上海,200437

会议文献：第六届中国药理学会补益药药理专业委员会学术研讨会论文集

会议名称：第六届中国药理学会补益药药理专业委员会学术研讨会

会议日期：20160816

会议地点：贵州遵义

主办单位：中国药理学会

出版日期：20160816

语　　种：中文

摘　　要：Object: Myocardial fibrosis is the endpoint pathology common to many cardiovascular disorders.We have previously shown that apocynin (APO), a naturally occurring NADPH oxidase inhibitor, significantly prevents the development of isoproterenol (ISO)-induced myocardial injury and fibrogenesis.Moreover, the cardio-protective effects of APO were associated with decreased production of reactive oxygen species (ROS) and suppressed expression of inflammatory cytokines and extracellular matrix (ECM) genes.In this study, we performed integrative analyses of miRNA and gene expression profiles to increase the molecular understanding of the cardio-protective activities of APO.

关 键 词：MYOCARDIAL injury  and  FIBROGENESIS APOCYNIN INTEGRATIVE analyses  miRNA-mRNA  INTERACTOME network